Anti-human Glycophorin A, Purified (Polyclonal) (rabbit IgG) from MyBioSource.com

anti-human Glycophorin A (GpA) Polyclonal Antibody targets the human Glycophorin A protein. This 131 amino acid, 16 KDa, transmembrane sialoglycoprotein spans the membrane of erythrocytes once and exists predominantly as a homodimer. GpA presents its N terminus at the extracellular surface of the human red blood cell, has a single transmembrane domain and an internal cytoplasmic C terminus. GpA contributes to the expression of blood group antigen M and N specificities, which work to prevent red blood cell aggregation in circulation. Studies show that GpA is expressed early on the cell surface during erythropoiesis as pluripotent stem cells are recruited to differentiate into erythrocytes. This makes GpA a useful marker for studying the developmental biology of hematopoietic progenitor cells. This polyclonal antibody recognizes various epitopes on the GpA protein. This antibody has been reported to work in flow cytometry, Western Blotting and ELISA. The 23 residue hydrophobic transmembrane domain has been shown to mediate non-covalent dimerization of the protein under conditions of SDS page (and in other detergents). We also sell a FITC conjugated version of this antibody (CL8020F)